对抗生素的多中心前性队列研究对OnabotulinumtoxinAAxin进行了研究
Elise Morocco1, Lannah Lua-Mailland2, Adrienne Werth3
1From the University of Southern California, Los Angeles, CA.
Urogynecology (Philadelphia, Pa.)
|December 17, 2024
概括
抗生素预防没有降低尿路感染 (UTI) 后的尿道感染 (BTX-A) 注射用于过度活动的膀. 这项研究发现,在接受抗生素和不接受抗生素的患者之间,尿路感染发生率没有显著差异.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 尿路感染 (UTI) 是注射内毒素A (BTX-A) 后的常见并发症.
- 目前的临床实践缺乏基于证据的抗生素预防指南,以防止BTX-A手术后的尿路感染.
研究的目的:
- 评估抗生素预防的有效性,以减少症状,培养证明的尿路感染率,在注射intradetrusorBTX-A后六周内.
- 为了比较不同的抗生素治疗方案,并确定与BTX-A后尿路感染发展相关的风险因素.
主要方法:
- 一项前性,观察性,多中心队列研究,涉及女性患者接受BTX-A治疗异常过活性膀.
- 在接受抗生素预防 (尼托福兰或trimethoprim-sulfamethoxazole) 和未接受预防的患者之间比较尿路感染率.
- 统计分析以确定所需的样本大小 (270名参与者),以检测尿路感染率有15%的差异.
主要成果:
- 综合症状,培养证明的尿路感染率为12.1%,在抗生素 (10.6%) 和无抗生素 (14.9%) 队列之间没有统计学上显著的差异 (P=0.29).
- 多变量分析确定了年龄较大,200单位的BTX-A剂量和自导管作为尿路感染的危险因素.
- 绝经后的状态和地理位置 (美国东北部) 与较低的尿路感染率有关.
结论:
- 抗生素预防并没有显著降低在注射BTX-A后症状性,培养证明的尿路感染的发生率.
- 尿路感染的危险因素包括年龄较大,BTX-A剂量较高和自导管,这表明有针对性的预防策略可能是合理的.
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