完全异位性HPV相关的宫内腺癌:一种罕见但潜在的侵袭性新生病现象
Roman E Zyla1,2, Karen L Talia3, Anjelica Hodgson1,2
1Department of Laboratory Medicine and Pathobiology, University of Toronto.
概括
只有异位性人类乳头瘤病毒 (HPV) 相关的宫内腺癌 (EA) 可能会产生不良结果. 这一发现挑战了对这些特定的HPV相关EA瘤的惰性过程的假设.
科学领域:
- 妇科瘤学 妇科瘤学
- 病理学 病理学 病理学
- 癌症研究 癌症研究
背景情况:
- 人类乳头瘤病毒 (HPV) 相关的内腺癌 (EA) 具有完全外生生长通常被认为具有缓慢的临床过程.
- 关于这些特定瘤类型的实际行为和预后的数据有限.
研究的目的:
- 调查与HPV相关的纯外生性EA的临床行为和结果.
- 为了确定这种生长模式是否与预期比以前假设的更差有关.
主要方法:
- 对73名与宫受限的HPV相关EA患者进行了回顾性分析,这些患者接受了初级手术治疗.
- 基于生长模式的瘤分类 (仅限于外生性与非外生性),瘤侵袭和病原学参数 (FIGO 2018次阶段,淋巴血管侵袭[LVI]).
- 评估临床结果,包括复发,转移和死亡.
主要成果:
- 在73个瘤中,只有4个 (6%) 呈现出完全异构的生长.
- 所有4种异体瘤都缺乏LVI和节点参与,并且没有接受辅助治疗.
- 尽管最初的特征是有利的,但50% (4人中的2人) 患有完全外性瘤的患者经历了复发并死于EA,与非外性瘤的<6%复发形成鲜明对比.
结论:
- 只有异位性HPV相关的EA可能与患者子组的不良结果有关.
- 这一发现需要进一步的研究,以确定这些瘤的预测特征和完善治疗策略.
- 对于纯外生性HPV相关的EA而言,假设一种惰的过程可能不适用于所有情况下.
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