沃尔萨德细胞巢/远距离输卵管和盆腔内皮质的过渡性细胞代谢来自储备细胞
Uiree Jo1, Chang Ohk Sung1, Kyu-Rae Kim1,2
1Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine.
概括
过渡性细胞代谢 (TCM) 起源于输卵管和骨盆中层下方的储备细胞. 这些细胞繁殖和分化成尿,其中雄激素受体 (AR) 起着关键作用.
科学领域:
- 妇科病理学 妇科病理学
- 细胞生物学 细胞生物学
- 基因组生成 基因组生成
背景情况:
- 过渡性细胞代谢 (TCM) 是一个常见的发现,类似于输卵管附近的尿路和盆腔介质体.
- 然而,TCM的起源和发展 (组织发生) 仍然在很大程度上未被阐明.
研究的目的:
- 为了研究过渡细胞代谢 (TCM) 的组织生成.
- 为了确定TCM的起源在输卵管和骨盆中层.
- 在TCM开发过程中分析关键标记物的免疫特征.
主要方法:
- 对31个输卵管上皮和35个骨盆中皮的TCM焦点进行了历史形态分析.
- 针对细胞激素17 (CK17),CK5/6,p63,GATA-3,雌激素受体 (ER) 和雄激素受体 (AR) 的免疫组合化学分析.
主要成果:
- 在这两个位置的TCM具有相似的组织学和免疫特征,但显示出明显的发育差异.
- 在输卵管上皮下出现CK17阳性储备细胞之前的TCM.
- 中皮也表现出CK17的表达,这表明内在的储备/干细胞潜力.
- 储备细胞分化为类似尿路细胞,表达CK5/6,p63和GATA-3.
- 观察到相互的ER和AR表达,具有显著更强的AR存在.
结论:
- 过渡性细胞代谢 (TCM) 起源于输卵管表皮和盆腔介质下方的储备细胞.
- 这些储备细胞繁殖和分化成尿膜.
- 雄激素受体 (AR) 可能在TCM的组织生成中发挥着重要作用.
相关概念视频
Uterine Tubes
498
The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
498
Renewal of Intestinal Stem Cells
2.5K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.5K
Histology of the Uterus
976
The uterine wall consists of three histological layers: the perimetrium, myometrium, and endometrium. The outermost perimetrium is a thin, serous membrane connected with the broad ligament on the sides, which helps anchor the uterus in the pelvic cavity. The thickest layer, myometrium, is mainly made up of smooth muscle tissue bundles. Its contractions are vital in facilitating the expulsion of the uterine lining, fetus, and placenta during menstruation and childbirth.
The endometrium is the...
The endometrium is the...
976
Classification of Epithelial Tissues: Stratified Epithelium
8.7K
Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
8.7K
Embryonic Connective Tissues
4.2K
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
4.2K
Ureters
356
The ureters are retroperitoneal tubes located on either side of the vertebral column. They are responsible for transporting urine from each kidney to the urinary bladder. These tubes have thick walls and are approximately 25-30 cm long. Their diameter is around 10 mm at the renal pelvis, gradually narrowing to 1 mm as the ureter obliquely enters the posterior bladder wall through the ureteric orifices. The shape of these orifices is slit-like, which helps to prevent urine backflow toward the...
356


