产前血红蛋白度和儿童长期神经认知发展
Michael O Mireku1, Michael J Boivin2, Roméo Zoumenou3,4
1College of Health and Science, University of Lincoln, Lincoln, United Kingdom.
The American journal of tropical medicine and hygiene
|December 17, 2024
概括
在怀孕期间保持足够的血红蛋白水平对于孩子的发育至关重要. 母亲的贫血与六岁儿童的神经认知分数较低有关,这凸显了产前护理的重要性.
科学领域:
- 产科和妇科 产科和妇科
- 儿科神经学 儿科神经学
- 血液学 血液学 血液学
背景情况:
- 孕期贫血,定义为血红蛋白 (Hb) <110 g/L,是撒哈拉以南非洲地区的重大公共卫生问题,导致母亲和婴儿发病率和死亡率.
- 孕妇Hb的生理和病理变化在怀孕期间发生,但它们对儿童神经认知发育的长期影响仍未得到充分研究.
研究的目的:
- 调查孕期母亲血红蛋白水平和轨迹与六岁儿童神经认知功能之间的关联.
- 识别整个妊娠期间母亲血红蛋白变化的独特模式及其与长期儿童发育结果的相关性.
主要方法:
- 一项前性队列研究,涉及6岁儿童,其母亲参加了抗疟疾药物试验.
- 孕妇的血红蛋白水平在怀孕期间和分娩时至少测量了两次.
- 基于小组的轨迹建模用于定义产前Hb轨迹,随后对儿童进行神经认知和运动功能评估.
主要成果:
- 确定了三个不同的母体Hb轨迹:持续贫血,贫血到非贫血,持续非贫血.
- 患有持续贫血或贫血至非贫血Hb轨迹的母亲生下的孩子与持续非贫血怀孕的母亲相比,神经认知得分明显较低.
- 具体来说,调整后的分析显示了贫血轨迹与儿童神经认知分数 (β = -6.8和β = -6.3) 之间存在显著的负相关性.
结论:
- 从怀孕的第二到第三个三个月保持母体血红蛋白水平在110g/L或以上,与儿童的最佳长期神经认知功能有关.
- 产前贫血,即使是短暂的,也可能对儿童的神经发育产生持久的有害影响.
- 这些发现强调了整个怀孕期间监测和管理母亲贫血的关键重要性,以支持最佳的儿童认知结果.
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