和性土元素在胆毛中的关联以及自发流产的风险
Meng Lin1, Yutong Wang1, Xiaoye Wang2
1Department of Medical Genetics, Center for Medical Genetics, Peking University, Beijing 100191, China; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Center for Medical Genetics, Peking University, Beijing 100191, China; National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing 100191, China; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China.
皮中的 (Ba) 暴露会增加自发流产的风险,而 (Mg) 和 (Rb) 暴露可能会减少它. 这项研究量化了这些和性土元素的风险.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 生物地质化学生物地质化学
背景情况:
- 和土元素 (AEE) 的暴露被怀疑会增加自发流产的风险.
- 缺乏子宫暴露于这些元素的直接证据.
研究的目的:
- 调查和性土元素度在胆小和自发流产风险之间的关联.
- 评估这些元素的单一和混合暴露的影响.
主要方法:
- 从自发性和诱导性流产中采集了胆管样.
- 用感应合血质谱法 (ICP-MS) 测量元素度.
- 使用了后勤回归,贝叶斯核机器回归 (BKMR) 和加权量子总和回归 (WQS) 模型.
主要成果:
- 高度与自发流产风险增加150%有关.
- 卢比 (Rb) 和 (Mg) 显示了自发流产风险的剂量依赖性降低.
- 混合暴露分析表明,随着暴露百分位数的增加,自发流产的可能性降低,Mg和Rb是关键的保护元素.
结论:
- 胆小中的较高Ba水平与自发流产风险有积极联系.
- 胆小中的Mg和Rb水平显示出与自发流产风险的负剂量反应关系.
- 这些发现突出了特定的和土元素对怀孕结果的差异影响.
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