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Updated: Jun 4, 2025

Ion Exchange Chromatography IEX Coupled to Multi-angle Light Scattering MALS for Protein Separation and Characterization
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Ion Exchange Chromatography IEX Coupled to Multi-angle Light Scattering MALS for Protein Separation and Characterization

Published on: April 5, 2019

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使用单一列与互补的离子交换和疏水相互作用染色学方法的反感性寡核酸的混合模式分离

Artaches A Kazarian1, Jung Hwa Lee1, Branko Mitasev1

  • 1Genetics Guided Dementia Discovery (G2D2), Eisai, Inc. 35 Cambridge Park Drive, Suite 200, Cambridge, MA, 02140, USA.

Journal of chromatography. A
|December 17, 2024
PubMed
概括

这项研究展示了混合模式染色学,将离子交换 (AEX) 和疏水相互作用染色学 (HIC) 结合起来,用于分析和净化反感性寡核酸. 该方法有效地将酸 (PS) 目标与二 (PO) 杂质分离,提供了有价值的净化策略.

关键词:
阳离子交换色谱学 阳离子交换色谱学反意义的寡核化物.疏水性相互作用色谱学 疏水性相互作用色谱学混合模式色谱学混合模式色谱学这是一个U形的保留装置.

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