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肺移植候选人的偶发性肺癌的预后

Clémentine Bouchez¹, Chahine Medraoui², Aurélie Cazes³

¹Université Paris Cité, Paris, France; Thoracic Oncology Department, CIC INSERM 1425, AP-HP.Nord, Hôpital Bichat-Claude Bernard, Paris, France.

Respiratory medicine and research

|December 17, 2024

概括

在肺移植 (LTx) 之前诊断的肺癌很少见,但禁忌该程序. 然而,在LTx后的扩散体中发现的肺癌显示出有希望的生存率,这表明局部非小细胞肺癌 (NSCLC) 的管理可能会发生转变.

科学领域:

肺部医学肺部医学
在瘤学瘤学.
移植手术移植手术

背景情况:

肺移植 (LTx) 中的偶然性肺癌通常在扩张或移植的器官中发现.
关于在候选人的LTx前评估期间诊断的肺癌的数据有限.
这项研究调查了在LTx.之前和之后发现的肺癌的临床和预后差异.

研究的目的:

描述在LTx前评估期间发现的肺恶性瘤.
为了确定在LTx后的扩展肺部中发现的肺癌.
为了比较这两个组的临床特征和结果.

主要方法:

回顾性,观察性,单中心研究.
对被提名参加巴黎-比查特肺移植计划 (2006-2022) 的患者的分析.
在LTx前的评估中发现的肺恶性瘤的特征与实验室的特征.

主要成果:

在288名不适合LTx的患者中,有20名 (6.9%) 患有肺癌 (15名非小细胞肺癌 - NSCLC).
在LTx前肺癌患者的一年生存率为55%.
在611名 (1%) 接受LTx的患者中,有6人患有NSCLC,一年生存率为66.7%.

结论:

在LTx前确诊的肺癌很少见,违反了移植,并使管理复杂化.
移植患者的肺部恶性瘤在扩散体中表现出令人鼓舞的一年生存率.
需要进一步的多中心研究来探索局部NSCLC的LTx标准的潜在变化.

关键词:

肺移植肺移植肺移植非小细胞肺癌是非小细胞肺癌.终端呼吸道功能衰竭 (TRI) 是一种呼吸系统衰竭.移植候选人移植候选人

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