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Updated: Jun 4, 2025

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纵向蛋白学揭示了PI3K-PAK1轴作为复发性结直肠肝转移的潜在目标

Daigo Gunji1, Yuichi Abe2, Satoshi Muraoka3

  • 1Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

Cell reports
|December 17, 2024
PubMed
概括

对5-FU化疗耐药的结肠直肠癌肝脏转移显示已激活的PAK激酶. PI3K抑制剂,如可潘利西布,显示出治疗这些耐药瘤的前景.

关键词:
CP: 癌症 癌症 癌症抗化学疗法耐药性 抗化学疗法耐药性结肠直肠癌肝脏转移 肝脏转移计算方法的计算方法.药物重新定位 药物重新定位蛋白原子的动力学

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