精准医学在制药产品开发中的研究:前景和机遇
Jorge E Martínez-Jiménez1, Indumathi Sathisaran2, Francheska Reyes Figueroa3
1Pharmacogenomics (PGx) Laboratory, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, 00936, United States.
International journal of pharmaceutics
|December 17, 2024
概括
精准医学 (PM) 需要个性化的药物配方. 本综述探讨了先进的配方策略,如增材制造和口腔可分散膜,用于量身定制的患者治疗.
科学领域:
- 制药科学 制药科学
- 药物运输 药物运输 药物运输
- 个性化医疗是个性化的医疗.
背景情况:
- 精准医学 (PM) 准备彻底改变药物疗法,要求新型药物产品设计.
- 在文献中存在一个空白,将PM原则与实际的,个性化的药物配方联系起来.
- 目前的制药制造业依赖于标准化产品,而不是患者特定需求.
研究的目的:
- 审查精准医学的最先进的配方方法.
- 弥合PM建议和为患者量身定制的药物产品之间的差距.
- 探索个性化药物的实用,点的护理制造解决方案.
主要方法:
- 在四个主要的科学数据库 (Scopus,SciFinder,Web of Science,PubMed) 进行了全面的文献搜索.
- 分析了当前在护理点PM配方和分布式制造方面的研究和开发.
- 确定并讨论了有前途的配方策略.
主要成果:
- 确定了几个关键的PM配方策略:分片,液体配方,复合药房,添加剂制造,药物浸,药物挤出和口腔可分散膜 (ODF).
- 护理点和本地分布式制造模式正在成为传统大规模生产的替代品.
- 突出了这些技术在实践中实施的挑战和机会.
结论:
- 先进的配方技术对于精准医学的常规可访问性至关重要.
- 使用点制造,如按需药房,为PM实施提供了一个新的前沿.
- 将临床研究与非临床药物产品开发联系起来,对于现实世界患者护理至关重要.
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