在密切相关的小鼠亚种及其杂交物种的自然种群中,宿主微生物群相互作用的生态进化动态
Susana C M Ferreira1,2,3, Víctor Hugo Jarquín-Díaz4,5,6,7, Aimara Planillo8
1Division of Computational Systems Biology, Center for Microbiology and Ecological Systems Science, University of Vienna, Djerassipl. 1, Vienna 1030, Austria.
Proceedings. Biological sciences
|December 17, 2024
概括
主体遗传学和环境塑造了肠道微生物. 宿主遗传距离强烈影响细菌,真菌和寄生虫群体,真菌表现出对感染的抵抗力. 这突显了宿主分歧.
科学领域:
- 生态生态学 生态生态学
- 进化生物学 进化生物学
- 微生物组研究 微生物组研究
背景情况:
- 密切相关的宿主经常共享共生体,但宿主遗传混合和环境因素对这些社区的影响尚未得到充分理解.
- 研究宿主-微生物群相互作用对于理解宿主-共生体共同进化动态至关重要.
研究的目的:
- 确定宿主遗传混合物和环境条件如何影响肠道原生生物和真核生物群落 (真菌,寄生虫).
- 将这些影响与来自混合区的野生捕获小鼠和在受控条件下的内生小鼠进行比较.
主要方法:
- 分析了两种室内老鼠亚种 (Mus musculus domesticus和M. m. musculus) 和它们的杂交物中的肠道 prokaryotic 和 eukaryotic 社区 (真菌,寄生虫).
- 在受控的实验室条件下,包括在干扰 (感染) 期间,比较野生捕获的小鼠和野生衍生的杂交小鼠的微生物组组成.
主要成果:
- 环境因素是野生捕获小鼠微生物组合的强有力的预测因素.
- 亚种的遗传距离显著影响了细菌,寄生虫和真菌群落,而杂交的效果较弱,特别是在真菌上.
- 与其他微生物组组成部分相比,真菌群体在野生和实验室环境中对感染引起的干扰具有更大的稳定性.
结论:
- 受环境因素影响的宿主遗传分歧和过,在塑造微生物群分歧方面发挥着重要作用.
- 亚种的遗传距离对微生物组的组成有着比杂交中的异构性更一致,更强大的影响.
- 研究结果提供了对主体微生物群相互作用的生态进化过程的见解.
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