默认模式网络子系统的有效连接和男性的自动吸烟行为
Mengzhe Zhang1, Jinghan Dang1, Jieping Sun1
1From the Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Journal of psychiatry & neuroscience : JPN
|December 17, 2024
概括
这项研究揭示了烟草使用障碍 (TUD) 患者的默认模式网络 (DMN) 中大脑连接的改变,将这些变化与吸烟动机和自动行为联系起来.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成研究 研究成研究
背景情况:
- 默认模式网络 (DMN) 包含交互的子系统,但它们在烟草使用障碍 (TUD) 和吸烟动机中的作用尚不清楚.
- 了解TUD的神经生物学特征对于开发有针对性的干预措施至关重要.
研究的目的:
- 评估TUD患者在三个DMN子系统中的因果连接性改变.
- 为了研究吸烟动机的神经生物学基础.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 用于男性吸烟者和非吸烟者.
- 动态因果建模 (DCM) 分析了DMN子系统 (中线核心,MTL,dMPFC) 的有效连接.
- 交叉验证检查了神经反应和吸烟原因之间的联系.
主要成果:
- 患有TUD的个体在准海马皮层 (PHC) 中表现出增强的自我连接,与戒断严重程度相关.
- 在背部中间前额叶皮层 (dMPFC) - DMN内,以及dMPFC-DMN和后侧环状皮层 - 前侧中间前额叶皮层 (PCC-aMPFC) 核心DMN之间,观察到有效连接的显著差异.
- 从侧側皮层到dMPFC的连接性下降预测了自动吸烟行为.
结论:
- 在TUD中,DMN子系统中的异常因果关系存在.
- 确定了自动吸烟行为的神经相关性.
- DMN子系统指标可以作为TUD异质性的潜在生物标志物.
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