低度尾粘膜瘤的监测,以检测其是否进展为皮瘤:结构化监测计划的结果
Enda Hannan1, Lorena Martin Roman1, Lukas O'Brien1
1The National Centre for Peritoneal Malignancy, Mater Misericordiae University Hospital, Dublin, Ireland.
概括
尾粘膜性瘤切除后的监测至关重要,因为6%的患者在3年内进展到 pseudomyxoma peritonei. 通过结构化监测,可以早期发现亚临床进展.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 在瘤学瘤学.
背景情况:
- 低度尾粘膜性瘤 (LAMN) 是一种罕见的尾瘤,有可能发展为尾瘤 (PMP).
- 由于进展率不明确,没有标准化的LAMN切除后监测协议.
- 这项研究旨在确定在结构化监测计划中LAMN向PMP的进展.
研究的目的:
- 为了评估手术切除后从LAMN到PMP的进展速度.
- 识别与疾病进展相关的风险因素.
- 评估结构化监测计划对PMP早期检测的有效性.
主要方法:
- 对从2013年到2021年接受LAMN监测的患者进行回顾性数据收集.
- 监测协议包括每年CT扫描和瘤标志物评估5年.
- 在随访期间,识别了在PMP中进展的患者.
主要成果:
- 在完成至少一年监测的83名患者中,6% (n=5) 进展为PMP.
- 病情进展的中位时间为23个月,风险在前3年内最高.
- 进展与M1b分期 (p=0.021) 和口外粘素 (p=0.04) 显著相关,但与T分期,边缘状态或穿孔无关.
结论:
- 观察到的进展率支持对LAMN患者进行尾切除术后监测的必要性.
- 患PMP的风险在诊断后的前三年内最高.
- 结构化监测计划有助于早期发现亚临床PMP进展.
关键词:
细胞减小手术 细胞减小手术超热内皮层内化学疗法 超热内皮层内化学疗法低度的尾粘膜性瘤.伪性瘤 (pseudomyxoma peritonei) 是一种发生在人体内的疾病.监控监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督更多相关视频
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