在非小细胞肺癌中成像NRF2激活,使用正子发射断层扫描
Hannah E Greenwood1, Abigail R Barber1, Richard S Edwards1
1School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London, UK.
Nature communications
|December 17, 2024
概括
使用[18F]FSPG的正子发射断层扫描可在非小细胞肺癌 (NSCLC) 中非侵入性检测NRF2激活. 这种成像标志物可以预测治疗耐药性,并使有针对性的治疗策略能够改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 分子成像学分子成像学
- 癌症生物学 癌症生物学
背景情况:
- 在非小细胞肺癌 (NSCLC) 中,NRF2-KEAP1通路的突变很普遍,导致治疗耐药性和患者预后不佳.
- 目前的诊断方法缺乏非侵入性方法来识别活体中NRF2通路激活.
研究的目的:
- 建立[18F]FSPG正子发射断层扫描作为NSCLC中NRF2激活的非侵入性成像生物标志物.
- 调查针对系统xc-传送器作为NSCLC的治疗策略.
主要方法:
- 在各种NSCLC小鼠模型中利用[18F]FSPG正子发射断层扫描 (PET) 成像 (正位素,患者衍生,基因工程).
- 在大量NSCLC患者中分析了NRF2相关的基因表达特征.
- 评估了使用抗体-药物合物对系统xc-的治疗向.
主要成果:
- [18F]FSPG PET成像显示了在不同NSCLC模型中对NRF2激活的敏感和特定检测.
- 确定了一种患者基因表达特征,可以预测[18F]FSPG的摄取,从而实现潜在的患者预选.
- 展示了系统xc-作为代谢脆弱性,与抗体药物联合疗法导致持续的瘤生长抑制.
结论:
- [18F]FSPG作为一个有价值的非侵入性成像生物标志物,用于预测NSCLC的治疗耐药性.
- 系统xc-是NSCLC治疗干预的可用药物标.
- 这些发现支持[18F]FSPG成像和NSCLC的系统xc-向治疗的临床评估.
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