抑郁症状和艾滋病毒病毒抑制:系统性审查和元分析
Bishan Huang1,2, Alitasha Younger3,4, Mary P Gallant5
1School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA. bhuang2@albany.edu.
AIDS and behavior
|December 17, 2024
概括
没有抑郁症的个人更有可能实现HIV病毒抑制. 治疗艾滋病毒感染者的抑郁症对于改善治疗坚持和健康结果至关重要.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 心理健康 心理健康
背景情况:
- 抑郁症是影响艾滋病毒感染者 (PLWH) 健康结果的已知因素.
- 了解抑郁症对艾滋病病毒抑制的具体影响,对于有效管理至关重要.
研究的目的:
- 通过元分析量化抑郁症和艾滋病病毒抑制之间的关联.
- 为了确定这种关联最明显的特定群体.
主要方法:
- 在主要数据库 (PubMed, Web of Science, EBSCO, OVID) 进行系统的文献搜索,寻找2012-2022年间的研究.
- 16项研究的元分析,包括80,103名参与者,遵守PRISMA指南.
- 用于分析的随机效应模型,通过Rayyan软件进行数据抽象.
主要成果:
- 没有抑郁症的个体显著更有可能实现病毒抑制 (OR 1.30;95% CI 1.15,1.48).
- 这种关联在一般PLWH人群和 cisgender女性中显著,但在 cisgender男性中没有统计学意义.
- 亚组分析显示,没有抑郁症和cisgender女性的病毒抑制之间存在正相关性 (OR 1.28;95% CI 1.09,1.50).
结论:
- 没有抑郁症与实现艾滋病毒抑制有积极的关联,特别是在 cisgender 女性.
- 对PLWH的公共卫生干预必须整合识别和管理抑郁症状的策略.
- 解决抑郁症可以改善治疗的坚持,减少并发症,并减轻阻碍病毒抑制的因素.
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