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探索从传统发酵饮料中分离出来的潜在益生菌的抗糖尿病活性

Bishwapriya Chutia¹, Partha P Dutta², Lunasmrita Saikia²

¹Department of Biotechnology, The Assam Royal Global University, Guwahati, Assam, 781035, India.

World journal of microbiology & biotechnology

|December 17, 2024

概括

来自发酵大米酒的益生菌细菌在治疗2型糖尿病方面显示出潜力. 巴西勒斯种类 (Bacillus sp.) 的存在 FRB_A(A) 显著降低了糖尿病大鼠的血糖和改善了抗氧化剂水平.

科学领域:

微生物学微生物学
生物技术是生物技术.
营养科学营养科学

背景情况:

2型糖尿病 (T2DM) 是一个全球性的健康问题,治疗选择有限.
益生菌,特别是某些细菌菌株,因其能够调节肠道微生物群并表现出抗糖尿病特性而得到认可.
传统的发酵食品是潜在有益的微生物的丰富来源.

研究的目的:

为了从阿萨姆邦发酵大米酒中分离和识别益生菌.
为了评估隔离细菌的体外抗氧化和抗高血糖潜力.
在大鼠模型中研究一个有前途的益生菌菌株的体内抗糖尿病功效.

主要方法:

从发酵大米酒中分离和选20种细菌菌株.
在体外评估益生菌特性,抗氧化活性和α-葡萄糖酶抑制.
在体内研究中,使用链毒素诱导的糖尿病大鼠接受了Bacillus sp. FRB_A(A) 在21天内.
在老鼠组织中分析血糖水平和内源性抗氧化剂 (脂质过氧化,谷氨,SOD,GPx) 概况.

主要成果:

五个分离物体表现出益生菌潜力,其中包括Bacillus sp. FRB_A(A) 和乙杆菌 sp. 的存在. FRB_B(S) 在体外表现出显著的抗氧化和抗α-葡萄糖酶活性.
巴西勒斯种类 (Bacillus sp.) 的存在在糖尿病大鼠中,FRB_A(A的使用显著降低了血糖水平,从458.00 ± 46.62 mg/dl降至108.20 ± 6.76 mg/dl (p < 0.001).
益生菌治疗导致内源性抗氧化剂状况的改善,与糖尿病对照相比,减少脂质过氧化和增强谷氨,超氧化脱氧化酶和谷氨过氧化酶的水平/活性.

结论:

巴西勒斯种类 (Bacillus sp.) 的存在 FRB_A(A),从发酵大米酒中分离出来,显示出显著的益生菌属性.
这种菌株具有显著的抗高血糖和抗氧化活性,这表明它在治疗2型糖尿病方面具有治疗潜力.
对Bacillus sp.进行进一步的研究 FRB_A(A) 可能导致用于T2DM管理的基于益生菌的新策略.

关键词:

乙杆菌 sp. 的存在.巴西勒斯种类 (Bacillus sp.) 的存在抗氧化剂是一种抗氧化剂.发酵食品是一种发酵食品.益生菌益生菌益生菌 2 型糖尿病 2 型糖尿病

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