抑制S100A9通过抑制RAGE表达和随后改善炎症来缓解急性胰腺炎
Chenfeng Shou1,2, Yuansong Sun1,2, Qiao Zhang1,2
1Department of Emergency Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Inflammation
|December 17, 2024
概括
抑制S100A9蛋白质可以改善胰腺损伤,并通过降低先进糖化最终产品 (RAGE) 的受体调节,减少急性胰腺炎 (AP) 的炎症. 这一发现澄清了S100A9的情况.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 急性胰腺炎 (AP) 是一种常见的炎症性腹部疾病.
- 严重的AP可以导致全身炎症和器官衰竭.
- S100A9蛋白是关键的炎症生物标志物,但其在AP中的作用尚不清楚.
研究的目的:
- 调查S100A9在AP中的作用.
- 阐明S100A9在AP中的作用的基本机制.
主要方法:
- 使用了AP和AR42J细胞系的小鼠模型.
- 在S100A9抑制后评估胰腺损伤和炎症因素 (IL-6,IL-1β,TNF-α).
- 评估了S100A9重组蛋白对AR42J细胞中素诱导的炎症的影响.
主要成果:
- 在AP小鼠中,S100A9抑制减少了胰腺损伤和炎症因子表达.
- 增加的S100A9水平与胰腺酸性细胞中RAGE表达率升高相关.
- 在AR42J细胞中,S100A9增强了RAGE表达,并加剧了炎症.
结论:
- 抑制S100A9通过降低RAGE的调节来缓解胰腺炎症.
- 针对S100A9可能是AP的治疗策略.
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