长期环境空气污染和严重精神障碍的风险:一个前性队列研究
Chuyu Pan1, Bolun Cheng1, Shiqiang Cheng1
1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
暴露于空气污染,包括PM2.5和NO2,显著增加重大精神疾病 (MDs) 的风险. 低收入和更高的遗传风险加剧了这种联系,强调了对空气质量控制的需要.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 精神病学是一个精神病学.
背景情况:
- 对空气污染对心理健康的影响的认识日益增长,与有关主要精神疾病 (MDs) 的流行病学证据有限形成鲜明对比.
- 现有的研究还没有充分探讨各种空气污染物与MDs发生率之间的特定关联.
研究的目的:
- 调查暴露于特定空气污染物对患重大精神疾病风险的影响.
- 探索社会经济地位和遗传风险对空气污染-MD关系的潜在改变影响.
主要方法:
- 对170,369名参与者进行前性队列研究,最初没有MDs.
- 使用土地利用回归模型估计对PM2.5,PM2.5-10,NO2和NO的暴露.
- 使用Cox比例危险模型分析发生的MD风险,并进行子组和相互作用分析.
主要成果:
- 观察到PM2.5 (HR: 1.16),NO2 (HR: 1.12) 和NO (HR: 1.10) 的高四分位数时,MDs的风险增加.
- 收入较低的参与者对与空气污染相关的MD风险的脆弱性增加.
- 发现了联合效应,具有最高的遗传风险和PM2.5暴露,MD的HR为1.63.
结论:
- 空气污染是主要精神疾病的重要环境风险因素.
- 公共卫生战略应包括空气污染控制,以减轻全球精神疾病负担.
- 社会经济地位和遗传倾向可以改变空气污染对心理健康的影响.
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