[帕金森病I-III阶段患者的膀功能障碍]
A A Pilipovich1, O V Vorob'eva1, S A Makarov1
1Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
|December 18, 2024
概括
膀功能障碍 (BD) 在帕金森病 (PD) 患者中很常见,影响生活质量. 抑郁症,前额功能障碍和男性性别在早期PD中预测BD.
科学领域:
- 神经学 神经学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 帕金森病 (PD) 是一种影响运动功能的神经退行性疾病.
- 膀功能障碍 (BD) 是PD中常见的非运动性症状,影响患者的生活质量.
- 患PD症状,多巴氨基疗法和BD之间的关系需要进一步调查.
研究的目的:
- 评估帕金森病 (PD) 患者膀功能障碍 (BD) 的患病率.
- 调查BD与各种PD症状之间的关联,包括运动和非运动方面.
- 确定PD患者BD的预测因子,并评估多巴胺类疗法的影响.
主要方法:
- 评估了113名患有PD (Hoehn和Yahr阶段I-III) 的患者队列.
- 使用标准化尺度,包括国际前列腺症状评分 (IPSS),统一帕金森病评分尺度 (UPDRS) 和其他用于评估症状.
- 进行了相关性和回归分析,以确定关系和预测因素.
主要成果:
- 观察到BD的高患病率 (89.4%),刺激性症状普遍存在,阻塞性症状在61%的患者中存在.
- BD 严重程度与年龄,PD 症状 (UPDRS 评分) 和非运动症状 (如抑郁和焦虑) 相相关.
- 抑郁症 (BDI),前额功能障碍 (FAB) 和男性性别被确定为BD发生的显著预测因素.
结论:
- 膀功能障碍在早期的PD中非常普遍,显著降低了生活质量.
- 阻塞性和刺激性膀症状在患有PD的男性和女性中都会发生.
- 阻塞性功能障碍与运动和非运动PD症状的强烈关联表明神经退行过程的参与.
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