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Updated: Jun 4, 2025

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
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在纳米磁盘中评估A2AR的功能和稳定性的带结合动力学

John M Pettersen1, Olivia McCracken1, Anne Skaja Robinson1

  • 1Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania.

Biophysical journal
|December 18, 2024
PubMed
概括

确定像腺素A2A受体 (A2A R) 这样的G蛋白合受体 (GPCR) 的药物位停留时间可以改善药物开发. 这项研究优化了A2A R纳米盘的稳定性,并描述了连接体结合动力学.

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