[在患有类风湿性关节炎的患者中使用甲状腺素的应用状态]
Yijun Han1, Xiaoli Chen1, Changhong Li1
1Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.
概括
在类风湿性关节炎 (RA) 患者中使用甲索特雷克萨特 (MTX) 剂量较低,通常是小剂量. 增加MTX的使用和剂量可能会提高RA患者治疗目标实现率.
科学领域:
- 类风湿病学 类风湿病学
- 临床药理学 临床药理学
- 免疫学 免疫学 免疫学
背景情况:
- 甲托雷克萨特 (MTX) 是类风湿性关节炎 (RA) 的基石疗法.
- 了解当前的MTX应用模式及其对疾病控制的影响对于优化RA管理至关重要.
研究的目的:
- 调查在风湿性关节炎 (RA) 患者中使用甲状腺素 (MTX) 的现状.
- 分析MTX使用与RA疾病控制之间的关系,包括治疗目标的实现.
主要方法:
- 对239名RA患者的临床和实验室数据进行了回顾性分析.
- 收集的数据包括MTX起始剂量,最大剂量,当前剂量以及停止治疗的原因.
- 统计分析包括t测试,曼-惠特尼U测试,奇平方测试,费舍尔的确切概率和多变量物流回归.
主要成果:
- 目前只有39.7%的RA患者正在使用MTX,通常是低剂量 (平均当前剂量:12.4±2.7毫克/周).
- 副作用是减少MTX剂量或停止使用的主要原因.
- 与非使用者相比,目前的MTX使用者实现治疗目标的比率更高 (52.6%与35.4%) 和较低的疾病活性评分 (DAS28-ESR:3.6±1.8与4.2±1.8).
结论:
- 在RA患者中,MTX的定期使用率很低,通常是小剂量,通常受到不良反应的限制.
- 定期使用MTX的RA患者表现出更好的疾病控制,更频繁地实现治疗目标.
- 增加MTX的使用和剂量可能会提高RA患者治疗目标实现率.
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