在不确定阶段的慢性乙型肝炎患者的自然史和预后
Hao Jiang1,2, Hongsheng Yu1,2, Yinan Huang1,2
1Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.
Journal of gastroenterology and hepatology
|December 18, 2024
概括
慢性乙型肝炎不确定的阶段患者有过渡到活跃疾病的高风险. 抗病毒疗法显著降低了这些患者患肝癌 (HCC) 和肝硬化风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 胃肠病学 胃肠病学
背景情况:
- 慢性乙型肝炎 (CHB) 包括一个"不确定的阶段",并没有被典型的疾病阶段定义得很好.
- 这一阶段的自然史和预后,特别是关于抗病毒治疗,需要进一步调查.
研究的目的:
- 为了调查CHB不确定阶段的自然史和预后.
- 评估抗病毒治疗对肝细胞癌 (HCC) 和肝硬化在不确定的CHB患者的发病率的影响.
主要方法:
- 追溯队列研究,比较不活跃和不确定CHB阶段.
- 分析过渡到免疫活性阶段和HCC和肝硬化发病率.
- 治疗权重的逆概率 (IPTW) 用于比较治疗与未治疗的不确定性CHB患者.
主要成果:
- 与不活跃的CHB患者相比,不确定的CHB患者的过渡到免疫活性阶段的风险明显更高.
- 未经治疗的不确定的CHB患者的HCC和肝硬化发病率高于接受治疗的患者.
- 抗病毒治疗是降低HCC和肝硬化风险的独立预测因素.
结论:
- 慢性肝炎不确定的阶段与进展到活性肝炎的高风险有关.
- 抗病毒治疗对于减轻未确定的CHB患者中HCC和肝硬化发病风险至关重要.
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