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血管风险因素与二级渐进性多发性硬化症中的灰质缩有关
Nevin A John1,2, Yingtong Li1, Floriana De Angelis3
1Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.
European journal of neurology
|December 18, 2024
概括
在次级渐进性多发性硬化症 (SPMS) 中,血管并发症和较高的并发症负担与灰质体积的减少有关. 然而,这些因素在两年内并没有显著影响大脑缩率.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 血管风险因素和并发症与多发性硬化症 (MS) 中的大脑缩有关.
- 在二次进展性多发性硬化症 (SPMS) 中,血管并发症 (VCM) 和大脑缩之间的联系不太清楚.
- 这项研究调查了VCM,并发症负担和SPMS中大脑缩之间的关联.
研究的目的:
- 为了检查VCM和SPMS中大脑缩之间的横截面和纵向关联.
- 评估整体并发症负担对SPMS中大脑缩的影响.
- 为了确定VCM或并发症的数量是否会影响随着时间的推移大脑缩的速度.
主要方法:
- 从MS-SMART试验中对445名参与者的特异分析.
- 记录了血管并发症 (高血压,高脂血症) 和其他并发症.
- 使用SIENAX和SIENA计算区域和整个大脑体积,以及缩率;多重线性回归被用于分析.
主要成果:
- VCM (高血压,高脂血症) 与皮质灰质体积的横截面下降有关.
- 较高的并发症数 (≥2) 也与皮质灰质体积减少有关.
- 在96周内,VCM/并发症数量与全脑或灰质缩率之间没有发现显著的关联.
结论:
- 患有SPMS和VCM或增加并发症负担的个体表现出大脑全脑和皮层灰质体积的减少.
- 没有发现VCM或并发症负担对随后2年的脑缩率有显著影响.
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