过敏导致严重的输血反应:一个病例报告
Myrthe E Sonneveld1, Sophie J Bernelot Moens1, Jolanda van den Akker2
1Department of Haematology Amsterdam University Medical Center, University of Amsterdam Amsterdam the Netherlands.
EJHaem
|December 18, 2024
概括
过敏性输血反应很少见,但可能与食物过敏有关. 这一案例突出了一个对过敏的患者,在从摄入的捐赠者输血血小板后经历过敏反应,强调了IgE介导反应.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 过敏 过敏是一种过敏.
背景情况:
- 输血反应发生在每1000次输血中约有2次.
- 过敏性输血反应较为罕见 (1万分之一),通常与血小板输血有关.
研究的目的:
- 描述一种罕见的过敏性输血反应的原因.
- 调查食物过敏和输血反应之间的潜在联系.
主要方法:
- 一个案例介绍了一名19岁的男性,因状细胞病而接受了血造细胞干细胞移植后的病例.
- 诊断评估包括针对和热菌素的特定免疫球蛋白E (IgE) 的过敏测试.
- 管理涉及输血与来自捐赠者的血小板,避免特定的食物触发器.
主要成果:
- 患者经历了血小板输血后的过敏性休克.
- 在该患者身上检测到和热素的高特异性IgE水平.
- 随后的血小板输血来自那些避免的捐赠者,没有任何事件.
结论:
- 与食物过敏原相关的IgE介导输血反应应考虑在已知食物过敏症患者经历严重反应时.
- 捐赠者的食物消费可能会在敏感的接受者中引发输血反应.
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