增强癌症治疗:先进的纳米车载输送系统用于奥里多尼
Yilin Su1, Lisha Liu1, Chongyang Lin1
1Institute of Urology, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, China.
Frontiers in pharmacology
|December 18, 2024
概括
一种天然化合物奥里多宁 (ORI) 显示出抗癌的前景,但其溶解性不佳. 正在探索ORI纳米输送系统,以提高其在癌症治疗中的有效性.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 纳米技术 纳米技术
背景情况:
- 奥里多宁 (ORI) 是Rabdosia rubescens的一个关键生物活性化合物.
- ORI表现出多种治疗作用,特别是抗癌,抗炎和免疫调节性质.
- ORI的临床应用受到水溶性差和生物利用率低的限制.
研究的目的:
- 审查基于ORI的纳米输送系统.
- 突出这些系统在改善奥里多宁在瘤学中的临床适用性方面的潜力.
- 为未来的研究确定当前的研究缺口.
主要方法:
- 对ORI纳米输送系统的文献综述.
- 分析克服ORI可溶性和生物利用性限制的策略.
- 专注于用于增强瘤学应用的纳米输送方法.
主要成果:
- 已经开发了各种纳米输送系统用于oridonin.
- 这些系统显示了提高ORI溶解度和生物可用性的潜力.
- 在ORI纳米输送研究方面取得了进展,但不足以用于临床使用.
结论:
- ORI纳米输送系统提供了一种有前途的策略,可以增强奥里多宁在癌症中的治疗潜力.
- 进一步的研究对于这些先进的药物输送系统的临床实施至关重要.
- 克服溶解性和生物可用性挑战是释放ORI充分临床实用性的关键.
更多相关视频
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
10.9K
09:09Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
5.9K
相关概念视频
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
01:27Tumor Immunotherapy
475
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
475
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
02:50Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K