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Jacob P Beard1, Sierra L Love2,3, John C Schmitz4,5

  • 1Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, United States.

ACS medicinal chemistry letters
|December 18, 2024
PubMed
概括

梅亚胺素是强效的抗癌药物,其向的是结合体. 新的类似物揭示了SF3B1中的特定残留物 (V1078) 对美亚素结合和抗癌活性至关重要.

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相关概念视频

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...