尿路微生物组分析作为一种非侵入性工具,用于识别系统性红斑狼和狼性炎中的生物标志物
Bo Shi1,2, Fei Chen2, Jianmin Gong3
1Department of Clinical Laboratory, Nanjing Jiangning District Hospital of Traditional Chinese Medicine (TCM), Nanjing, China.
Frontiers in cellular and infection microbiology
|December 18, 2024
概括
尿路微生物组的变化与系统性红斑狼 (SLE) 有关. 尿液中的特定细菌可以作为SLE的诊断生物标志物,可能会影响免疫调节.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 细菌组的变化与系统性红斑狼 (SLE) 病原发生有关.
- 尿路微生物组在SLE中的作用在很大程度上仍未被探索.
研究的目的:
- 为了描述SLE患者的尿路微生物群.
- 调查尿路微生物组与SLE的临床参数之间的相关性.
- 探索尿路微生物群对SLE的诊断潜力.
主要方法:
- 来自SLE患者 (有或没有狼性炎) 和健康对照者的尿液沉积物的16S rRNA测序.
- 接收器操作特征 (ROC) 曲线分析用于诊断效率.
- 对于微生物临床联系的斯皮尔曼相关性和功能预测 (Picrust2).
主要成果:
- 尿液微生物群有效地区分了SLE患者与健康对照.
- 像*Sphingomonas*和*Lachnospiraceae*这样的特定属与临床标记 (维生素D,蛋白尿) 相相关.
- 其他属 (*Pedobacter*, *Aquabacterium*, *Delftia*, *Achromobacter*) 显示与蛋白尿和白蛋白与肌素比率 (ACR) 有反向相关性.
结论:
- 这项研究揭示了SLE患者的尿路微生物组失生症.
- 已识别的细菌种群可以作为SLE的诊断生物标志物.
- 尿路微生物组的功能能力表明,它在SLE相关的免疫调节中发挥了作用.
关键词:
16S 16S 16S 16S 16S 16S 16S 16S 16S 16S 16S 16S 16S生物标志物生物标志物狼性炎是一种神经炎症.系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.尿路中的微生物群.更多相关视频
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