体重变化对移植结果的影响:系统性审查和元分析
Mehmet Kanbay1, Dimitrie Siriopol2, Sama Mahmoud Abdel-Rahman3
1Department of Internal Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey.
Diabetes, obesity & metabolism
|December 18, 2024
概括
移植脏后体重增加增加了移植失败的风险,但不增加死亡率或心血管事件. 这一发现有助于优化脏移植接受者移植后护理策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 代谢医学是一种代谢医学.
背景情况:
- 接受移植的人经常面临代谢并发症,如体重变化,影响结果.
- 移植后体重增加与患者/移植结果之间的联系需要进一步澄清.
研究的目的:
- 系统地审查和分析关于体重增加对移植结果的影响的证据.
- 为了告知临床实践和改善移植后护理策略.
主要方法:
- 在PubMed和Scopus的系统文献搜索到2024年8月.
- 包括成年脏移植接受者,在移植后显著增加体重,与对照组相比.
- 专注于结果:全因死亡率,移植存活率,心血管事件和急性排斥.
主要成果:
- 对11项研究的综合分析发现,体重增加与全因死亡率,心血管事件或急性排斥之间没有显著联系.
- 体重增加与移植失败风险增加有显著联系 (HR 1.58,p < 0.001).
结论:
- 移植后显著的体重增加与移植失败的风险更高有关.
- 在研究观察期间,体重增加并没有增加死亡,心血管事件或急性排斥的风险.
相关概念视频
Kidney Transplant I: Introduction
2
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
2
Kidney Transplant III: Nursing Management
3
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
3
Kidney Transplant II: Surgical Procedure
2
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
2
Acute Kidney Injury IV: Diagnostic Studies and Prevention
8
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
8
Acute Kidney Injury III: Clinical Manifestations
2
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
2
Chronic Kidney Disease III: Interprofessional Care
2
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
2


