可视化PIM-1蛋白功能及其与PI3K/Akt/mTOR通路的相互作用,通过FRET生物传感器通过其活性位点进行调节

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Updated: Jun 4, 2025

FRET Microscopy for Real-time Monitoring of Signaling Events in Live Cells Using Unimolecular Biosensors
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FRET Microscopy for Real-time Monitoring of Signaling Events in Live Cells Using Unimolecular Biosensors

Published on: August 20, 2012

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Na Li1,2,3, Youyi Zhao4, Danbo Wang1

  • 1Cancer Hospital of Dalian University of Technology, Shenyang, China.

Biotechnology journal
|December 18, 2024
PubMed
概括

调查PIM-1激酶中的活性位点揭示了Lys67调节了基质结合和PI3K/Akt/mTOR信号传递. Pro81/Asn82对ATP结合至关重要,而Asp167对酶活性的影响很小.

关键词:
费特·弗雷特 (FRET FRET) 是一家在美国的船只.在PI3K/Akt/mTOR中使用.这就是PIM-1的意义.活跃的网站 活跃的网站生物传感器生物传感器

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