通过增强RONS生产,提高性等离子激活水的抗癌效率
Bolun Pang1, Zhijie Liu1, Yuting Gao1
1State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China.
ACS applied materials & interfaces
|December 18, 2024
概括
性等离子激活水 (PAW) 通过产生更高水平的活性氧和物种 (RONS) 来提供更绿色,更有效的抗癌治疗. 这种创新方法显示出强大的抗癌作用,并防止小鼠的瘤生长.
科学领域:
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
背景情况:
- 传统的抗癌药物带来环境和健康风险.
- 血激活水 (PAW) 是一种绿色替代品,但酸性PAW的RONS持续时间和剂量有限.
- 开发具有选择性,具有成本效益,副作用较少的抗癌疗法至关重要.
研究的目的:
- 建议性PAW作为一种增强的RONS技术用于抗癌疗法.
- 研究性PAW的RONS生成途径和抗癌机制.
- 评估性PAW对癌细胞和体内瘤生长的疗效.
主要方法:
- 产生性PAW并将其RONS水平 (NO2-,H2O2,ONOO-/O2•-) 与酸性PAW进行比较.
- 在性PAW中使用拾尸器分析了RONS生成途径.
- 评估了 in vitro 对癌细胞的抗癌作用和 in vivo 对小鼠异种移植瘤的疗效.
主要成果:
- 与酸性PAW相比,性PAW产生的关键RONS水平大约是酸性PAW的10倍.
- 在性与酸性PAW中确定了明显的RONS生成途径.
- 性PAW显示出协同作用的抗癌作用,增加细胞内ROS/RNS,并有效抑制异种移植瘤的生长.
结论:
- 性PAW是一种强效,环保的抗癌治疗技术.
- 它的有效性与高RONS剂量和特定的生成途径有关.
- 这项研究为优化PAW在癌症治疗中的生物化学活性提供了基本的见解.
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