早期儿童暴露于化物和认知神经发育:基于人口的纵向研究
L G Do1, A Sawyer2, A John Spencer3
1School of Dentistry, Faculty of Health and Behavioural Sciences, The University of Queensland, Australia.
Journal of dental research
|December 18, 2024
概括
儿童早期化物暴露对于预防牙至关重要,对认知神经发育没有任何不良影响. 这项研究证实了化物.
科学领域:
- 公共卫生 公共卫生
- 神经科学是一个神经科学.
- 儿科牙科 儿科牙科
背景情况:
- 公众对化物的虫预防益处的信心是必不可少的.
- 人们对早期化物暴露和认知神经发育存在担忧.
- 需要高质量的证据来解决正在进行的辩论.
研究的目的:
- 研究早期化物暴露对认知神经发育的潜在影响.
- 使用韦克斯勒成人智力表第四版 (WAIS-IV) 评估智商 (IQ).
- 检查一生暴露于化水和牙化与智商分数之间的关联.
主要方法:
- 利用了来自澳大利亚国家儿童口腔健康研究 (NCOHS) 的数据.
- 估计的百分比终身暴露在化水中 (%LEFW) 和评估的牙.
- 在2022-2023年为357名年龄在16-26岁的参与者注射WAIS-IV.
- 采用多变量回归模型来控制混因素.
主要成果:
- 平均全尺度智商 (FSIQ) 分数为109.2 (95% CI:107.8-110.5).
- 回归模型显示,%LEFW或牙化与FSIQ之间没有显著的不良关联.
- 对100%LEFW与0%LEFW进行调整后的β为1.07 (95%CI:-2.86,5.01).
- 对牙化与非化进行调整后的β值为0.28 (95% CI: -3.00, 3.57).
- 非劣势测试表明暴露和非暴露组之间的FSIQ分数相当.
结论:
- 儿童早期接触化物不会对认知神经发育产生负面影响.
- 研究结果支持在空预防计划中继续使用化物.
- 这项研究提供了强有力的证据,证明化物暴露对认知功能的安全性.
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