代谢功能障碍相关的脂肪性肝病与甲状腺癌之间的关联
Sang Yi Moon1, Minkook Son2,3, Jung-Hwan Cho4
1Department of Internal Medicine, Dong-A University College of Medicine, Busan, Republic of Korea.
与代谢功能障碍相关的脂肪性肝病 (MASLD) 和相关疾病会增加甲状腺癌的风险. 这项韩国研究将MASLD和代谢/酒精相关的肝病与较高的甲状腺癌发病率联系起来.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 是代谢综合征的肝脏表现.
- MASLD与甲状腺癌风险之间的关系尚未得到充分证实.
研究的目的:
- 调查韩国人口中MASLD,心脏代谢风险因素 (CMRF) 和甲状腺癌发病率之间的关联.
- 检查肝病的连续性,从CMRF的脂肪性肝病 (SLD) 到MASLD和代谢/酒精相关的肝病 (MetALD),与甲状腺癌风险相关.
主要方法:
- 分析了来自国家健康查计划 (2009-2010) 的214,502名韩国成年人 (≥40岁) 的队列.
- 参与者根据SLD和CMRF状态进行分类:没有CMRF的SLD,没有CMRF,MASLD和MetALD的SLD.
- 甲状腺癌发病率在平均随访时间为9.61年内使用多变量调整的考克斯比例危险模型进行了跟踪.
主要成果:
- 共有2761名 (1.3%) 参与者患上了甲状腺癌.
- 与没有CMRF和SLD的人相比,患有CMRF (HR 1.33),MASLD (HR 1.36) 和MetALD (HR 1.40) 的人的甲状腺癌风险明显更高.
- MetALD与甲状腺癌发生率显著相关,特别是在男性中.
结论:
- 除CMRF外,MASLD和MetALD与韩国人群中甲状腺癌的发病率增加有关.
- 这项研究为CMRF-MASLD-MetALD连续和甲状腺癌风险之间的关联提供了新的证据.
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