在种子甲虫中基因表达的性别特异性主导地位
Philipp Kaufmann1, Johanna Liljestrand Rönn2, Elina Immonen1
1Department of Ecology and Genetics, Evolutionary Biology, Uppsala University, 75234 Uppsala, Sweden.
Molecular biology and evolution
|December 18, 2024
概括
性对抗性选择可以通过基因表达的性别特异性主导性来维持遗传变异. 这项研究发现,在基因调节中,性别特异性显著占主导地位,特别是在性别偏差的基因中,支持其在平衡选择中的作用.
科学领域:
- 进化遗传学的进化遗传学
- 人口遗传学 人口遗传学
- 基因调节 基因调节
背景情况:
- 性对抗性 (SA) 选择可以维持遗传变异,特别是性别特异性主导性.
- 基因表达中的性二态是常见的,但在基因调节中的性别特异性主导地位是鲜为人知的.
- 主导逆转,即在不同的环境中有利于等位基因,可以驱动平衡选择.
研究的目的:
- 为了研究基因表达中的性别特异性支配.
- 为了确定基因调节变异是否表现出性别特异的主导地位.
- 探索SA选择在通过调控变异维持遗传变异中的作用.
主要方法:
- 在种子甲虫 (Callosobruchus maculatus) 的同卵性系之间利用了三种交叉.
- 分析基因表达数据以确定主导效应和性别特异性差异.
- 在具有性别特异优势的转录上进行基因本体学丰富分析.
主要成果:
- 基因表达变异的支配效应在性别之间具有正相关性 (r = 0.330.44).
- 586个转录在基因表达中表现出明显的性别特异性主导地位.
- 性别特异性的优势在性别偏差的基因中更为普遍,并且与SA表型相关,如代谢过程和拉皮胺的标途径.
结论:
- 基因调节中的性别特异性优势是种子甲虫的重要因素.
- 这种现象有助于在SA选择下维持基因变异.
- 性别主导的监管变体在平衡选择中发挥作用.
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