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新生儿肠道微生物群和发展食物敏感性和过敏的风险
Ryohei Shibata1, Yumiko Nakanishi2, Wataru Suda3
1Laboratorie for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan; Department of Pediatric Surgery, Graduate School of Medicine, Chiba University, Chiba City, Japan.
The Journal of allergy and clinical immunology
|December 18, 2024
概括
新生儿肠道微生物群肠道类型,特别是Bifidobacterium占主导地位的肠道类型,与食物敏感化 (FS) 和食物过敏 (FA) 的风险降低有关. 这些发现强调了早期肠道微生物组合在婴儿健康中的重要性.
科学领域:
- 微生物组研究的研究.
- 婴儿免疫学 婴儿免疫学
- 过敏的发展过敏的发展.
背景情况:
- 食物敏感性 (FS) 和食物过敏 (FA) 在婴儿期出现,FS是FA的风险因素.
- 人们越来越认识到肠道微生物群在FS和FA中的作用,但其在新生儿中的特定功能仍然不清楚.
研究的目的:
- 使用肠型鉴定对新生儿肠道微生物群进行分类.
- 调查肠道微生物群肠型与FS和FA的发展之间的关联.
主要方法:
- 结合了来自日本两项出生队列研究的肠道微生物组和便短链脂肪酸数据.
- 应用肠型对婴儿 (1周至7岁) 和母亲的微生物组数据.
- 利用多变量回归模型来评估微生物群,肠型和FS/FA风险之间的关联.
主要成果:
- 从2563个微生物组中确定了六种不同的肠型.
- 在1个月大的婴儿中,与1周大的婴儿相比,肠道细菌 (例如Bifidobacterium) 和FS/FA发育之间发现了更强烈的关联.
- 与较高便酸相关的双杆菌占主导地位的肠型,显示FS和FA的风险最低,特别是蛋白敏感性.
结论:
- 在新生儿中,肠道微生物群肠型鉴定确定了具有不同风险的不同群体,对食物敏感性和食物过敏产生不同的风险.
- 早期的肠道微生物组组成是婴儿食物过敏的病理生物学的一个重要因素.
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