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在长期限制卡路里和耐力运动从业者中对生物衰老生物标志物的多分子分析:一个横截面研究

Giovanni Fiorito¹, Valeria Tosti², Silvia Polidoro³

¹Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

|December 18, 2024

概括

卡路里限制 (CR) 和运动 (EX) 在人类中显示出有前途的抗衰老作用. 这两种干预措施都减少了生物年龄 (BioAge) 生物标志物,CR影响肠道微生物组,EX影响结肠组织,这表明具有组织特异性的益处.

科学领域:

衰老的研究研究.
长寿科学是一种科学.
发现生物标志物的发现.

背景情况:

卡路里限制 (CR) 和体育炼 (EX) 在动物模型中延长健康和寿命.
它们对人类生物衰老的影响尚未完全理解.
在奥米克和生物年龄 (BioAge) 指标方面的进步使新的评估方法成为可能.

研究的目的:

为了比较长期CR从业者,耐力运动员 (EX) 和久坐控制 (WD) 的BioAge生物标志物.
通过使用多基因分析来研究CR和EX对人类衰老的影响.
确定衰老背后的共同和干预特异性的分子机制.

主要方法:

用9个血液生物标志物的复合得分PhenoAge来评估BioAge.
多原子分析包括DNA甲基化,RNAseq,代谢学和代谢基因组学.
年轻的西方饮食 (yWD) 被试作为BioAge计算的参考.

主要成果:

与WD对照组相比,CR和EX组表现出明显较低的BioAge生物标志物.
在肠道微生物组和血液中,CR显示了更低的BioAge.
EX在结肠粘膜衍生的表观遗传和转录基因标记物中显示出较低的生物年龄.
确定了像氧化应激这样的共同途径和像乙脂代谢这样的独特途径.

结论:

CR和EX干预似乎在人类中具有抗衰老作用.
观察到CR和EX对生物年龄的组织特异性影响.
这些发现提供了对生活方式干预机制和未来研究方向的见解.

关键词:

生物衰老生物衰老卡路里限制卡路里限制它们是多种多种多种多种多种的.氧化应激是一种氧化应激.身体炼就是体力炼.

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