使用纳米粒子准乳腺瘤细胞外基质和细胞层
Faris Anad Muhammad1, Farag M A Altalbawy2,3, Viralkumar Mandaliya4
1College of Pharmacy, Alnoor University, Nineveh, Iraq.
概括
纳米粒子通过向瘤层和细胞外基质 (ECM) 提供了治疗乳腺癌的新方法. 这些微小的颗粒改善了药物输送,并可以改变与癌症相关的纤维细胞和免疫细胞,以获得更好的治疗结果.
科学领域:
- 在瘤学瘤学.
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 乳腺癌是女性普遍存在的恶性瘤,受到其瘤层和细胞外基质 (ECM) 的显著影响.
- 由蛋白质和蛋白质甘氨酸组成的ECM提供结构支持,但可以阻碍药物透到瘤中.
- 诸如癌症相关纤维细胞 (CAF) 和免疫细胞等流体成分极大地影响瘤的进展和治疗耐药性.
研究的目的:
- 审查基于纳米颗粒的治疗方法的最新进展,以准乳腺瘤瘤和ECM.
- 探索纳米颗粒如何增强抗癌药物的输送,包括化疗和小分子药物.
- 研究纳米粒子在调节CAF和免疫细胞等结构元件以及重塑ECM中的作用.
主要方法:
- 在乳腺癌治疗中纳米粒子应用的文献综述.
- 对瘤层透和药物输送相关的纳米粒子属性的分析.
- 对纳米粒子介导的CAF和免疫细胞重编程研究的审查.
主要成果:
- 纳米颗粒显示出瘤流层中的提高透性和保留性,增强药物输送.
- 有针对性的纳米粒子输送可以克服ECM障碍,提高药物的疗效.
- 纳米颗粒显示出改变结构元件以增强治疗反应的潜力.
结论:
- 纳米技术为克服与乳腺瘤微环境相关的挑战提供了一个有希望的战略.
- 向的纳米粒子传递和 stromal 调制为乳腺癌治疗提供了新的治疗途径.
- 进一步研究纳米粒子-ECM和纳米粒子-细胞相互作用对于临床转化至关重要.
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