紧急数值评分尺度:克罗恩病成年人的心理评估
Marla Dubinsky1, Aisha Vadhariya2, Sylvia Su3
1Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
紧急性数值评分表 (NRS) 有效地测量了克罗恩病 (CD) 患者的肠道紧急性. 3-5分的下降意味着改善,而2分或更低的分数表明缓解.
科学领域:
- 胃肠病学 胃肠病学
- 临床心理学 临床心理学
- 健康 结果 研究 研究 结果
背景情况:
- 肠急性是克罗恩病 (CD) 患者的重要生活质量问题.
- 紧急数值评分表 (NRS) 是患者报告的结果,衡量肠急症的严重程度.
- 验证紧急NRS对于评估CD治疗疗效至关重要.
研究的目的:
- 评估紧急NRS在中度至重度活跃CD的成年人中的心理特征.
- 为了建立有意义的改善和缓解肠急症的门.
- 支持在临床试验和实践中使用紧急NRS.
主要方法:
- 用VIVID-1 mirikizumab第3期研究的汇总数据进行了心理测量分析.
- 使用了紧急NRS,患者全球严重性评级 (PGRS) 和患者全球变化印象 (PGIC).
- 用PGRS和PGIC作为杆来估计有意义的改善和缓解的门.
主要成果:
- 紧急NRS证明了良好的测试-重试可靠性和与类似措施的中等相关性.
- 它与内镜和实验室评估的相关性很弱.
- 该尺度对变化敏感,区分患者子组并反映治疗效果.
- 在紧急NRS上减少3-5个点表明有意义的改善.
- 在紧急NRS上得分≤2表明缓解.
结论:
- 紧急NRS表现出强大的心理测量特性,用于评估CD患者的肠道紧急情况.
- 成功确定了有意义的改善和缓解值.
- 紧急NRS是一种验证的工具,用于评估CD群体的肠道紧急情况.
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