COVID-19康复性血的安全概况
Michael J Joyner1, Rickey E Carter2, R Scott Wright3,4
1Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA. joyner.michael@mayo.edu.
Current topics in microbiology and immunology
|December 18, 2024
概括
COVID-19康复性血 (CCP) 是一个安全的治疗选择. 广泛的研究和现实世界的数据表明,CCP具有较低的严重不良事件风险,与标准血输血相比较.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 有关COVID-19康复性血 (CCP) 安全性的担忧存在,原因是血产品的历史问题和当代使用.
- 常规使用新鲜冷血 (FFP) 提供了血产品安全性的基准.
研究的目的:
- 为了评估COVID-19康复性血的安全概况.
- 将CCP的安全性与新鲜冷血和标准输血实践进行比较.
主要方法:
- 来自FDA授权的CCP扩展访问计划的安全数据的分析.
- 对现实世界的证据,实用试验和随机对照试验的审查.
- 评估严重的不良事件,包括输血相关的循环过载和输血相关的急性肺损伤.
主要成果:
- 中央对手的整体风险概况与FPF的风险概况类似.
- 严重不良事件的发生率很低,即使在住院患者中也存在并发症.
- 没有观察到抗体依赖增强或血栓栓塞事件的发病率增加.
结论:
- COVID-19康复性血是一种安全的治疗产品.
- 综合的安全数据应该减轻对未来的流行病准备和血部署的担忧.
相关概念视频
Blood Transfusion and Agglutination
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Characteristics and Functions of Blood
Blood is specialized connective tissue comprising about 8% of the body mass. It has a thick, liquid extracellular matrix that contains cells, dissolved proteins, and electrolytes, making it five times more viscous than water. Blood is warm, around 38°C, and has an alkaline pH ranging from 7.35 to 7.45.
The primary function of blood is to transport oxygen and carbon dioxide between tissues and the lungs. Oxygenated blood is bright red, while oxygen-depleted blood is darker. It also carries...
The primary function of blood is to transport oxygen and carbon dioxide between tissues and the lungs. Oxygenated blood is bright red, while oxygen-depleted blood is darker. It also carries...
Blood Transfusion
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...


