相关实验视频

Updated: May 6, 2026

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients

Published on: September 25, 2018

双特异性酸酶23在非小细胞肺癌中起到有前途的预后生物标志物的作用

Seula Keum¹, Yoon Ji Lee¹, Jung-Woong Kim²

¹Department of Life Science, Chung-Ang University, Seoul, 06974, Republic of Korea.

Genes & genomics

|December 18, 2024

概括

双特异性酸酶23 (DUSP23) 在刚性瘤微环境中被上调,并促进非小细胞肺癌 (NSCLC) 的进展. DUSP23作为NSCLC的预后标志物,表明患者的生存率不佳.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物物理学的生物物理.

背景情况:

瘤微环境的机械性质对于非小细胞肺癌 (NSCLC) 的进展至关重要.
双特异性酸酶23 (DUSP23) 是已知的机械反应基因,但其在NSCLC中的特定作用仍然未被描述.

研究的目的:

调查DUSP23在NSCLC进展中的临床意义.
探索DUSP23在NSCLC细胞行为中的功能性作用.

主要方法:

在模仿正常和癌症组织的不同矩阵刚度下分析了DUSP23表达.
使用公共患者数据库检查了DUSP23的预后意义.
在DUSP23沉默NSCLC细胞中进行了基于细胞的测定和转录组分析.
使用考克斯回归和卡普兰-梅尔分析构建了一个预后风险模型.

主要成果:

在刚性矩阵中,DUSP23的表达上调,与NSCLC和乳腺癌的不良预后相关.
DUSP23静音降低了NSCLC细胞的扩散和入侵.
转录组分析显示,在DUSP23耗尽后,细胞周期和细胞骨组织途径发生了显著的变化.
一个基于DUSP23的预后模型确定了高风险的NSCLC患者,总生存时间较短.

结论:

DUSP23是NSCLC临床显著的预后标志物.
DUSP23在促进NSCLC进展方面发挥作用,可能通过调节细胞周期和细胞骨组织.

关键词:

生物信息学分析在 DUSP2323 中.在NSCLCLC中,我们可以看到NSCLCLC.预测生物标志物预测生物标志物对转录组进行分析.

更多相关视频

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...