转化生长因子-β在风湿性关节炎相关的肺纤维化患者的唾液中增加
Timothy M Wilson1, Matthew Bolt2, Andrew Stahly3
1Division of Rheumatology, Thomas Jefferson University, Philadelphia, PA.
Rheumatology (Oxford, England)
|December 18, 2024
概括
在患有肺纤维化 (RA-PF) 的类风湿性关节炎患者中,液TGF-β水平升高,与疾病严重程度相关. 这一发现可能会改善RA-ILD的查和治疗.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 生物标志物发现发现
背景情况:
- 类风湿性关节炎 (RA) 患者有5-10%的风险发展间歇性肺病 (ILD),这是死亡的主要原因.
- 目前的生物标志物不足以识别RA肺纤维化 (RA-PF) 的RA患者.
- 这项研究研究了RA-ILD的唾液基生物标志物.
研究的目的:
- 在唾液中识别肺部生物标志物,以区分RA患者的肺纤维化.
- 探索TGF-β和MUC5B基因在RA-ILD病原发生中的作用.
主要方法:
- 在37名RA-PF患者和30名没有ILD的RA患者的和血清TGF-β水平的比较 (RA-no-ILD).
- 通过DNA分析评估MUC5BILD风险等位基因的存在.
- 使用高分辨率CT (HRCT) 和肺功能测试 (PFTs) 量化肺病严重程度.
主要成果:
- 唾液TGF-β在RA-PF患者中显著高 (P < 0.001) 和与HRCT纤维化 (P = 0.005) 和PFTs (P < 0.05) 相相关.
- 具有MUC5BILD风险基因型的RA-PF患者的唾液TGF-β水平较高 (P = 0.038).
- 两组之间没有观察到血清TGF-β水平的显著差异.
结论:
- 唾液TGF-β水平在RA-PF中升高,与疾病严重程度和MUC5B风险等位基因相关.
- 这些发现表明,在RA患者中,ILD的潜在新查方法.
- 唾液TGF-β可能会为RA-ILD的向治疗策略提供信息.
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