系统性硬化症相关的便失禁:一个范围审查,重点关注被忽视的表现
Alain Lescoat1,2, François Zimmermann1,2, Charles D Murray3
1Department of Internal Medicine and Clinical Immunology, Rennes University Hospital, Rennes, France.
本范围审查总结了关于系统性硬化症 (SSc) 中便失禁 (FI) 的知识. 它强调了对于这种经常被忽视的SSc表现需要更好的研究和治疗策略.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 临床研究 临床研究
背景情况:
- 便失禁 (FI) 是系统性硬化症 (SSc) 的重要表现.
- 目前关于SSc患者FI的知识需要全面总结.
- 了解SSc中FI的流行病学,病原体和临床表现至关重要.
研究的目的:
- 对SSc.中的FI现有文献进行范围审查.
- 总结有关 SSc. 的 FI 流行病学,致病性,临床表现和调查的当前知识.
- 确定研究中的差距,并提出未来的研究议程.
主要方法:
- 使用了基于Arksey和O'Malley的范围审查方法.
- 在PubMed (Medline) 和Web of Science数据库中进行了文献搜索.
- 数据提取使用了一个预定义的模板,用于包含的文章.
主要成果:
- 在选了454个摘要后,包括61篇文章,其中32篇是原创文章.
- 在SSc中FI的流行率在原始研究中从0.4%到77%不等.
- 内部关节功能障碍,血管病变和矩阵沉积是关键的致病因素;保守的管理和门测量是常见的.
- 韦克斯纳FI评分和UCLA SCTC-GIT 2.0是经常使用的患者报告结果.
结论:
- 这是第一个在SSc.的背景下探索FI的范围审查.
- 调查结果强调需要改进SSc中的FI的诊断和治疗策略.
- 提出了一项新的研究议程,以解决这种被忽视的SSc表现.
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