抗药性HIV患者中的神经病变 在雅加达接受治疗的患者
Ibnu A Ariyanto1, Fitri Octaviana2, Churi Wardah3
1Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Journal of infection in developing countries
|December 18, 2024
概括
抗药性突变在感染艾滋病毒的人群中很常见 (PLWH) 经历ART治疗失败在印度尼西亚. 这些突变与艾滋病毒相关感官神经病变的风险增加有关.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 药物基因组学 药物基因组学
背景情况:
- 抗逆转录病毒疗法 (ART) 对于治疗艾滋病毒至关重要.
- 一些接受ART治疗的人表现出病毒清除不良,可能与艾滋病毒相关的感官神经病变有关.
- 了解治疗失败机制对于优化艾滋病毒治疗至关重要.
研究的目的:
- 调查艾滋病毒治疗失败的个体中药物耐药性突变的存在.
- 评估耐药性突变与艾滋病毒相关的感官神经病变之间的关联.
主要方法:
- 在长期ART治疗后,分层患者的HIVRNA水平≥1000副本/毫升.
- 分析了对核酸 (NRTI),非核酸 (NNRTI) 和蛋白酶抑制剂 (PI) 的耐药性突变的HIV多基因.
- 使用简要的外周神经病查工具评估并发感染,传播途径和神经病变.
主要成果:
- 在大多数情况下,药物耐药性突变被确定 (6/7为NRTI/NNRTI,1/7为PI).
- 具体的突变包括M184V,M41L,T215F (NRTI);K103N,G190A (NNRTI);以及M46I,I50V,I54V,V82A,N88DGS (PI).这些突变的特点在于它们的基因与基因之间的关系.
- 静脉注射药物使用很常见 (4/7),耐药性突变与神经病变的更高风险相关 (p = 0.016).
结论:
- 药物耐药性突变在检查的HIV治疗失败中很普遍.
- 这些突变间接与PLWH中外围神经病变的风险增加有关.
- 识别耐药性模式对于有效的艾滋病毒治疗策略至关重要.
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