CD101阴性中性粒细胞在I型干扰素介导的结核病免疫病原发生过程中的致病作用
Mohd Saqib1, Shreya Das1, Tanvir N Nafiz1
1Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA.
Cell reports
|December 18, 2024
概括
被称为中性粒细胞的免疫细胞在结核病 (TB) 中起着关键作用. 这项研究发现,不成熟的中性粒细胞会损害对Mycobacterium tuberculosis (Mtb) 的免疫反应,恶化结核病.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 病变的发生和发病.
背景情况:
- 中性粒细胞对于对抗Mycobacterium tuberculosis (Mtb) 的宿主防御至关重要.
- 中性粒细胞异质性表明结核病 (TB) 发病过程中具有复杂的作用.
- 不同的中性粒细胞子集可能会对结核病结果产生不同的影响.
研究的目的:
- 研究中性粒细胞种群在结核病原发生过程中的独特作用.
- 阐明结核病中中性粒细胞功能障碍背后的机制.
- 在结核病中调节中性粒细胞功能的治疗点.
主要方法:
- 流细胞测量以根据CD101表达来确定中性粒细胞种群.
- 在体外测试以评估不同中性粒细胞子集的Mtb化.
- 在体内研究以评估中性粒细胞种群对结核病进展的影响.
- 分析细胞因子和化学因子参与中性粒细胞的招募和功能.
主要成果:
- 确定了两个不同的中性粒细胞种群,CD101阴性 (CD101-ve) 和CD101阳性 (CD101+ve).
- CD101中性粒细胞未成熟,表现出减少的Mtb细胞分裂,并通过I型干扰素 (IFN-Is) 招募到肺部.
- 由IFN-I驱动的CD101-ve中性粒细胞的招募促进了Mtb的细胞外持久性,上皮损伤和表面活性剂的产生受损,由G-CSF和CXCR2介导.
结论:
- CD101中性粒细胞通过损害宿主免疫力,在结核病中发挥病原性作用.
- 不成熟的中性粒细胞的IFN-I依赖性招募加剧了结核病免疫病原发生.
- 准IFN-I或CD101中性粒细胞的招募途径可能为结核病提供治疗策略.
关键词:
CP: 免疫学 免疫学CP: 微生物学 微生物学在G-CSF中使用.化学因子受体 化学因子受体细胞外的Mycobacterium 结核病菌主体导向疗法 主体导向疗法低密度的中性粒细胞.肺上皮细胞 肺上皮细胞中性粒细胞的动员.中性粒细胞子集中性粒细胞子集组织损伤 组织损伤这是一种I型干扰子.更多相关视频
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