主观认知投诉和未来痴呆和认知障碍的风险,这是最重要的
Jaclyn M Fox1, Danielle J Harvey2, Jagnoor Randhawa1
1Davis Department of Neurology, University of California, Sacramento, USA.
概括
除了记忆问题之外,主观认知衰退 (SCD) 投诉,例如记住约会和理解语言,可能是早期神经退行性疾病的信号. 更广泛的认知投诉评估有助于识别有风险的老年人.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 认知心理学 认知心理学
背景情况:
- 主观认知衰退 (SCD) 在老年人中很常见,但预测进展为轻度认知障碍 (MCI) 或痴呆症的特定投诉类型尚未确定.
- 现有的研究往往侧重于记忆障碍,可能忽视神经退行症的其他早期指标.
研究的目的:
- 为了确定日常认知量表 (ECog) 中哪些特定的投诉与从正常认知向MCI/痴呆症的进展最强烈相关.
- 为了确定超越记忆问题的认知投诉是否预测老年人诊断进展.
主要方法:
- 对415名老年人进行长度研究,平均每年监测5年.
- 考克斯的比例危险模型被用来评估ECog投诉与MCI/痴呆症进展之间的关联.
- 统计模型对抑郁症作为潜在的混因素进行了控制.
主要成果:
- 记忆,语言,视觉空间,规划和组织领域的多个投诉与诊断进展有关.
- 在考虑了抑郁症之后,难以记住预约和难以理解口头指示仍然是进展的重要预测因素.
- 研究结果表明,更广泛的认知投诉与早期疾病检测有关.
结论:
- 主观认知衰退的投诉,特别是那些与记忆和理解口语信息相关的投诉,是神经退行性疾病风险的有价值指标.
- 建议对各种认知投诉进行全面评估,而不仅仅是与记忆相关的投诉,以确定患有MCI/痴呆症风险的个人.
- 这些发现支持在老年人群中扩大认知查的范围,以改善神经退行性疾病的早期检测.
相关概念视频
01:30Dementia
94
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
94
01:30Cognitive Development During Adulthood
50
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
50
01:30Negative and Cognitive Symptoms of Schizophrenia
43
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
43
01:23Assessment of the Cardiovascular System I: Subjective Data
278
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
278
01:26Alzheimer's Disease: Overview
444
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
444
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
95
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
95