未来的脊柱反射嵌入了初级运动皮层输出输出中
Tatsuya Umeda1,2,3, Osamu Yokoyama4, Michiaki Suzuki4
1Department of Developmental Physiology, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki, Aichi 4448585, Japan.
Science advances
|December 18, 2024
概括
子的初级运动皮层 (M1) 在肢体运动期间预测和整合脊柱反射. 这种"交叉"通路允许M1通过预测和利用反射活动来优化运动指令.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 系统神经科学 系统神经科学
背景情况:
- 哺乳动物的肢体运动涉及到自愿的皮层命令和非自愿的脊柱反射之间的复杂协调.
- 大脑将下降的运动输出与脊髓反射活动相结合的神经机制在很大程度上是未知的.
研究的目的:
- 研究运动相关的皮质区域,特别是主要运动皮质 (M1) 在预期的肢体运动中如何与脊柱反射协调.
- 阐明神经通路涉及集成下降的运动命令和关联反精确的运动执行.
主要方法:
- 从运动相关的皮质区域,关神经元和前肢肌肉的同时电生理记录,子执行达到任务.
- 对神经活动的分析,以识别M1对 afferent活动和脊柱反射组件的编码.
- 对 afferent 途径进行实验性破坏,以评估其对肌肉活动的贡献.
主要成果:
- 主要运动皮层 (M1) 活动编码了与前肢运动相关的随后的 afferent 活动.
- 此外,M1还编码了肌肉活动的一个组成部分,该成分是由 afferent反驱动的,这是脊柱反射的特征.
- 干扰 afferent 途径选择性地减少了肌肉活动的脊柱反射组成部分.
结论:
- M1利用一个"交叉"通道,将直接下降输出与脊柱反射调节相结合,以驱动肌肉活动.
- M1采用内部前模型来前计算和整合未来的脊柱反射,以获得最佳的运动输出.
- 这种机制允许适应性和精确的四肢运动,尽管持续的脊柱反射影响.
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