自主调节与基于正念的减轻慢性病的压力:一个随机对照试验
Jinhee Jeong1,2, Yingtian Hu3, Matias Zanuzzi1,2
1Division of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
基于正念的压力减轻 (MBSR) 在慢性病 (CKD) 患者中显著降低了交感神经系统 (SNS) 活动. 这项为期8周的计划降低了对心理压力的同情反应能力,这表明对CKD自主功能有好处.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 心理学 心理学 心理学
背景情况:
- 慢性病 (CKD) 与交感神经系统 (SNS) 的过度活化有关,增加了心血管疾病的风险.
- 了解调节CKD中SNS活动的干预措施对于患者的治疗结果至关重要.
研究的目的:
- 研究一项为期8周的基于正念的压力减轻 (MBSR) 计划对CKDIII-IV阶段患者的SNS活动的影响.
- 为了比较MBSR与积极对照,健康增强计划 (HEP) 的影响.
主要方法:
- 一项随机对照试验,涉及29名CKD患者 (III-IV阶段).
- 参与者被分配到MBSR或HEP组.
- 肌肉交感神经活动 (MSNA) 在8周的干预前后使用微神经图在休息状态和压力操纵期间 (精神算术,手握,冷压力测试) 进行测量.
主要成果:
- 在精神压力期间的MSNA反应性中观察到群体和时间之间的显著相互作用 (P=0.029).
- 干预后,MBSR显著降低了MSNA对心理算法的反应性 (P<0.001),效果大小很大 (g=-0.858).
- 在MBSR组的手握运动中也注意到MSNA反应性降低,而在休息的MSNA和对冷压器测试的反应在两组都保持不变.
结论:
- 在CKD患者中,八周的MBSR有效地降低了交感神经系统对精神压力和手握运动的反应性.
- 正念训练是一种可行的干预措施,可以为CKD的自主功能障碍提供临床益处.
- MBSR显示出作为一种治疗策略的潜力,以减轻与CKD中SNS过度激活相关的心血管风险.
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