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Updated: Jun 4, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

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双重突变DNMT3AAML:一种独特的亚型,经历了DNA损伤增加和不良预后

Emma L Boertjes1, Sanne Massaar1, Annelieke Zeilemaker1

  • 1Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands.

Blood advances
|December 18, 2024
PubMed
概括

突变DNMT3A通过胺DNA糖酶 (TDG) 损害了DNA修复,这是基切除修复 (BER) 中的一个关键酶. 在急性髓性白血病 (AML) 中,双重突变DNMT3A与较差的生存率和增加的DNA损伤有关.

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