累积赤字脆弱指数和关系状况预测了多发性骨髓瘤的生存率
Nadine Abdallah1, Paul Dizona2, Amanika Kumar3
1Division of Hematology, Mayo Clinic, Rochester, MN.
Blood advances
|December 18, 2024
概括
通过累积赤字指数评估的脆弱性显著影响新诊断的多发性骨髓瘤 (MM) 的生存率和症状负担. 单身状态也会影响结果,强调需要重新评估治疗期间的脆弱性和社会支持.
科学领域:
- 血液学 血液学 血液学
- 老年学是指老年学的学科.
- 在瘤学瘤学.
背景情况:
- 评估多发性骨髓瘤 (MM) 的脆弱性通常依赖于临床试验数据,对患者报告的结果和健康的社会决定因素的信息有限.
- 在现实环境中新诊断的MM患者的脆弱性和社会经济地位 (SES) 的预后值需要进一步调查.
研究的目的:
- 评估新诊断的MM患者累积赤字脆弱指数 (FI) 和关系/社会经济地位 (SES) 的预后影响.
- 检查虚弱和患者报告的结果之间的关联,包括症状负担和生活质量.
主要方法:
- 在梅奥诊所对515名新诊断的MM患者 (2005-2018) 的回顾性研究.
- 累计赤字脆弱性指数 (FI) 是使用日常生活活动和并发症数据计算的.
- 脆弱性定义为FI ≥0.15;分析与疾病阶段,移植,生存和患者报告结果的关联.
主要成果:
- 虚弱 (39%的患者) 和未婚状态与更高的疾病阶段,减少早期移植的可能性和独立的生存率下降有关.
- 虚弱的患者报告说,疲劳,疼痛和生活质量得分更差.
- 虚弱状态是动态的,在3-12个月内~25%恶化和<10%改善;SES与生存没有独立关联.
结论:
- 累积赤字FI有效地识别了现实MM队列中较高的症状负担和降低的生存率.
- 虚弱是动态的,需要在治疗期间重新评估;社会支持是临床评估的有价值的预后指标.
相关概念视频
01:24Kaplan-Meier Approach
94
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
94
01:21Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:15Assumptions of Survival Analysis
96
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
96
01:20Comparing the Survival Analysis of Two or More Groups
149
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
149
01:19The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K