在健康的老年人中,抗生素使用和随后的认知衰退和痴呆风险
Yiqing Wang1, Zhen Zhou1, Jonathan C Broder1
1From the Clinical and Translational Epidemiology Unit (Y.W., A.T.C.), and Division of Gastroenterology (Y.W., A.T.C.), Massachusetts General Hospital and Harvard Medical School, Boston; School of Public Health and Preventive Medicine (Z.Z., J.C.B., R.L.W., S.G.O., R.W., J.R.), Monash University, Melbourne; Menzies Institute for Medical Research (Z.Z.), University of Tasmania, Australia; Department of Pharmacy Practice and Science (E.J.E.. M.E.E.), College of Pharmacy, and Department of Family Medicine (M.E.E.), Carver College of Medicine, University of Iowa, Iowa City; Department of Immunology and Infectious Diseases (A.T.C.), Harvard T.H. Chan School of Public Health, Boston; and Cancer Center (A.T.C.), Massachusetts General Hospital, Boston, MA.
老年人使用抗生素并没有增加痴呆症或认知能力下降的风险. 这项研究发现,在最初健康的个体中,抗生素暴露与长期认知健康结果之间没有联系.
科学领域:
- 微生物学 微生物学
- 神经学 神经学
- 老年学是指老年学的学科.
背景情况:
- 抗生素会破坏肠道微生物群,导致失生症.
- 之前的研究表明,dysbiosis和认知功能之间存在联系,但前性数据有限.
研究的目的:
- 研究抗生素使用与健康老年人认知衰老之间的潜在关联.
主要方法:
- 利用来自澳大利亚老年人前性观察研究的数据.
- 通过处方记录评估抗生素使用情况 (解剖治疗化学代码J01).
- 使用线性混合模型和Cox比例危险模型分析了与认知衰退,痴呆症和认知障碍的关联.
主要成果:
- 抗生素使用与痴呆症或认知障碍,没有痴呆症 (CIND) 的风险增加无关.
- 没有发现与认知得分的纵向变化有显著的关联.
- 结果在各种分析中保持一致,包括累积使用和特定的抗生素类别.
结论:
- 在最初健康的老年人中,抗生素使用与发生痴呆症,CIND或加速认知衰退无关.
- 这些发现不支持抗生素诱导的肠道微生物组破坏和痴呆风险之间的联系.
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