口腔炎症和微生物组失调症加剧了慢性移植对宿主疾病
Yui Kambara1, Hideaki Fujiwara2, Akira Yamamoto2
1Department of Hematology, Oncology and Respiratory Medicine, Okayama University Medical School, Okayama, Japan.
Blood
|December 18, 2024
概括
血造细胞移植 (HCT) 后口腔细菌失衡 (失生症) 会使慢性移植对宿主疾病 (cGVHD) 恶化. 向口腔微生物可以预防或治疗cGVHD.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 口腔微生物群在全身性疾病中的作用是公认的,但其对移植与宿主疾病 (GVHD) 的具体贡献仍然不清楚.
- 血造细胞移植 (HCT) 患者容易患上口腔并发症,如粘膜炎,可能会改变口腔微生物群.
研究的目的:
- 在HCT患者中调查口腔功能失调和慢性GVHD (cGVHD) 之间的关联.
- 使用小鼠模型阐明口腔失生症对cGVHD病原体的作用机制.
主要方法:
- 分析HCT患者的口腔微生物群,这些患者患有粘膜炎和cGVHD.
- 在小鼠HCT模型中使用双边关节绑定诱导口腔失生症.
- 在小鼠中评估细菌转位,免疫细胞激活和cGVHD严重程度.
主要成果:
- 在HCT后的口腔失生症,即使是移植后的环胺,与增加的cGVHD相关.
- 小鼠模型显示,口腔失生症加剧了cGVHD,增加了口腔和肠道组织中的细菌负载,特别是Enterococcaceae.
- 肠球菌向淋巴结的迁移激活了呈抗原的细胞,促进了炎症T细胞和全身炎症.
结论:
- 口腔失生症是cGVHD发展和进展的一个重要因素.
- 致病性口腔细菌可以转移到肠道,在HCT期间放大系统性炎症.
- 针对口腔微生物组的干预措施显示出减轻小鼠cGVHD的潜力,这表明治疗潜力.
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