在产前暴露于酸盐和酸盐替代品,与膜板表面血管在分娩时的关系
Emily S Barrett1, David Skrill2, Elaine Zhou3
1Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA; Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
The Science of the total environment
|December 18, 2024
概括
孕期暴露于甲酸盐可能会改变胎盘血管结构,观察到更多的动脉分支和更短的段落. 胎盘血管化的这些变化可能会影响胎儿的发育.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
背景情况:
- 孕妇面临着无处不在的内分泌干扰酸盐的暴露.
- 胎盘是一个脆弱的器官,动物研究表明甲酸对发育和血管化的影响.
研究的目的:
- 为了研究妊娠期甲酸和甲酸替代暴露与人类胎盘胆板表面血管化之间的联系.
- 检查与甲酸代谢产物相关的胎盘血管化的新型标志物.
主要方法:
- 甲酸盐和替代代物被测量在154名孕妇的第一季度尿液中.
- 使用二维和三维数字成像分析胎盘,以量化胆管板表面血管结构.
- 使用权重定量g计算和多变量线性回归模型来评估关联,并对共变量进行调整.
主要成果:
- 酸盐混合物暴露与较长的总动脉弧长,较短的平均动脉弧长和增加的动脉分支点有关.
- 双异丁甲酸 (DiBP),双异尼甲酸 (DiNP) 和双基甲酸 (DEHP) 的代谢物显示出最强的关联.
- 与酸盐替代代物代谢物的相关性通常朝着相同的方向,但较弱.
结论:
- 孕期甲酸暴露可能与胎盘胆板表面血管结构的改变有关,其特征是分支增加和动脉段缩短.
- 这些血管变化可能会影响胎盘输液,并代表了酸盐影响胎儿发育的机制.
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